Originally posted by BlaqueKatt
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Longstanding theories about depression suggest that important neurotransmitters—chemicals that brain cells use to communicate—are out of balance in depression. But it has been difficult to prove this.
The new England Journal of Medicine states:
This review of major depressive disorder is a comprehensive account of the genetic, biochemical, and neurophysiological changes that have been implicated in the disorder. No single mechanism can account for all the clinical variations in this condition. The monoamine oxidase theory can explain many of the actions of antidepressants, but genetic factors, stress, and psychosocial factors also play a part in depression.
From WebMD:
Although it is widely believed that a serotonin deficiency plays a role in depression, there is no way to measure its levels in the living brain. Therefore, there have not been any studies proving that brain levels of this or any neurotransmitter are in short supply when depression or any mental illness develops. Blood levels of serotonin are measurable -- and have been shown to be lower in people who suffer from depression – but researchers don't know if blood levels reflect the brain's level of serotonin.
Also, researchers don't know whether the dip in serotonin causes the depression, or the depression causes serotonin levels to drop.
Although it is widely believed that a serotonin deficiency plays a role in depression, there is no way to measure its levels in the living brain. The Antidepressant medications that work on serotonin levels -- SSRIs (selective serotonin reuptake inhibitors) and SNRIs (serotonin and norepinephrine reuptake inhibitors) -- are believed to reduce symptoms of depression, but exactly how they work is not yet fully understood.
Also, researchers don't know whether the dip in serotonin causes the depression, or the depression causes serotonin levels to drop.
Although it is widely believed that a serotonin deficiency plays a role in depression, there is no way to measure its levels in the living brain. The Antidepressant medications that work on serotonin levels -- SSRIs (selective serotonin reuptake inhibitors) and SNRIs (serotonin and norepinephrine reuptake inhibitors) -- are believed to reduce symptoms of depression, but exactly how they work is not yet fully understood.
All they have is a drug that makes you feel better. They don't know why it works, only that it does. I can write a paper stating that Depression is caused by a lack of Alcohol or other drugs in the Blood Stream and get the same results.
There is no scientific proof or empirical data that supports the Chemical Imbalance Myth. All you have is a promotion from Big Pharma, the media, shrinks, and anyone else that can make a buck off of it.
Don't want to call it a myth, that's fine. Just don't call it a fact.

)...has never helped. For a lot of reasons.
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